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adeno-associated virus (aav) designer receptors exclusively activated by designer drug (dreadd) vectors  (Addgene inc)


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    Addgene inc adeno-associated virus (aav) designer receptors exclusively activated by designer drug (dreadd) vectors
    Activation of prefrontal PV + neurons in male mice affects the expression of anxiety-like and depressive-like behaviors under baseline and stressful conditions. Top left, Representative image of <t>mCherry-DREADD</t> virus expression in the PrL and IL regions of <t>the</t> <t>PFC.</t> Top right, Schematic representation of experimental design. a–d , In the EPM test, UCMS interacted with the chronic activation of prefrontal PV + neurons to modulate the time spent in the open arms ( a ; * p = 0.0441; ** p = 0.0052), but no other significant interactions were observed. e – h , In the OF test, UCMS decreased time in the center ( e ; * p = 0.011), increased thigmotaxis ratio ( g ; * p = 0.0244), and increased overall activity ( h ; ** p = 0.0019). i , j , In the marble-burying test, a significant UCMS effect was driven by a higher number of marbles buried by UCMS/hM3DGq mice compared with their nonstressed controls (** p = 0.0038; i ); a similar effect was observed in the splash test ( j ), with decreased time spent grooming by UCMS/hM3DGq mice compared with their nonstressed controls (** p = 0.0088). k , In the CPA test, significant effects of stress and virus were detected; Tukey’s post hoc analyses revealed that the aversion score of mice from the UCMS/hM3DGq was lower than that of control mice (* p = 0.021). N = 8–11/group (C/mCherry, N = 8; UCMS/mCherry, N = 11; C/hM3DGq, N = 8; UCMS/hM3DGq, N = 9). Data are presented as the mean ± SEM.
    Adeno Associated Virus (Aav) Designer Receptors Exclusively Activated By Designer Drug (Dreadd) Vectors, supplied by Addgene inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    adeno-associated virus (aav) designer receptors exclusively activated by designer drug (dreadd) vectors - by Bioz Stars, 2026-10
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    1) Product Images from "Sex-Specific Timelines for Adaptations of Prefrontal Parvalbumin Neurons in Response to Stress and Changes in Anxiety- and Depressive-Like Behaviors"

    Article Title: Sex-Specific Timelines for Adaptations of Prefrontal Parvalbumin Neurons in Response to Stress and Changes in Anxiety- and Depressive-Like Behaviors

    Journal: eNeuro

    doi: 10.1523/ENEURO.0300-22.2023

    Activation of prefrontal PV + neurons in male mice affects the expression of anxiety-like and depressive-like behaviors under baseline and stressful conditions. Top left, Representative image of mCherry-DREADD virus expression in the PrL and IL regions of the PFC. Top right, Schematic representation of experimental design. a–d , In the EPM test, UCMS interacted with the chronic activation of prefrontal PV + neurons to modulate the time spent in the open arms ( a ; * p = 0.0441; ** p = 0.0052), but no other significant interactions were observed. e – h , In the OF test, UCMS decreased time in the center ( e ; * p = 0.011), increased thigmotaxis ratio ( g ; * p = 0.0244), and increased overall activity ( h ; ** p = 0.0019). i , j , In the marble-burying test, a significant UCMS effect was driven by a higher number of marbles buried by UCMS/hM3DGq mice compared with their nonstressed controls (** p = 0.0038; i ); a similar effect was observed in the splash test ( j ), with decreased time spent grooming by UCMS/hM3DGq mice compared with their nonstressed controls (** p = 0.0088). k , In the CPA test, significant effects of stress and virus were detected; Tukey’s post hoc analyses revealed that the aversion score of mice from the UCMS/hM3DGq was lower than that of control mice (* p = 0.021). N = 8–11/group (C/mCherry, N = 8; UCMS/mCherry, N = 11; C/hM3DGq, N = 8; UCMS/hM3DGq, N = 9). Data are presented as the mean ± SEM.
    Figure Legend Snippet: Activation of prefrontal PV + neurons in male mice affects the expression of anxiety-like and depressive-like behaviors under baseline and stressful conditions. Top left, Representative image of mCherry-DREADD virus expression in the PrL and IL regions of the PFC. Top right, Schematic representation of experimental design. a–d , In the EPM test, UCMS interacted with the chronic activation of prefrontal PV + neurons to modulate the time spent in the open arms ( a ; * p = 0.0441; ** p = 0.0052), but no other significant interactions were observed. e – h , In the OF test, UCMS decreased time in the center ( e ; * p = 0.011), increased thigmotaxis ratio ( g ; * p = 0.0244), and increased overall activity ( h ; ** p = 0.0019). i , j , In the marble-burying test, a significant UCMS effect was driven by a higher number of marbles buried by UCMS/hM3DGq mice compared with their nonstressed controls (** p = 0.0038; i ); a similar effect was observed in the splash test ( j ), with decreased time spent grooming by UCMS/hM3DGq mice compared with their nonstressed controls (** p = 0.0088). k , In the CPA test, significant effects of stress and virus were detected; Tukey’s post hoc analyses revealed that the aversion score of mice from the UCMS/hM3DGq was lower than that of control mice (* p = 0.021). N = 8–11/group (C/mCherry, N = 8; UCMS/mCherry, N = 11; C/hM3DGq, N = 8; UCMS/hM3DGq, N = 9). Data are presented as the mean ± SEM.

    Techniques Used: Activation Assay, Expressing, Virus, Activity Assay, Control



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    Activation of prefrontal PV + neurons in male mice affects the expression of anxiety-like and depressive-like behaviors under baseline and stressful conditions. Top left, Representative image of <t>mCherry-DREADD</t> virus expression in the PrL and IL regions of <t>the</t> <t>PFC.</t> Top right, Schematic representation of experimental design. a–d , In the EPM test, UCMS interacted with the chronic activation of prefrontal PV + neurons to modulate the time spent in the open arms ( a ; * p = 0.0441; ** p = 0.0052), but no other significant interactions were observed. e – h , In the OF test, UCMS decreased time in the center ( e ; * p = 0.011), increased thigmotaxis ratio ( g ; * p = 0.0244), and increased overall activity ( h ; ** p = 0.0019). i , j , In the marble-burying test, a significant UCMS effect was driven by a higher number of marbles buried by UCMS/hM3DGq mice compared with their nonstressed controls (** p = 0.0038; i ); a similar effect was observed in the splash test ( j ), with decreased time spent grooming by UCMS/hM3DGq mice compared with their nonstressed controls (** p = 0.0088). k , In the CPA test, significant effects of stress and virus were detected; Tukey’s post hoc analyses revealed that the aversion score of mice from the UCMS/hM3DGq was lower than that of control mice (* p = 0.021). N = 8–11/group (C/mCherry, N = 8; UCMS/mCherry, N = 11; C/hM3DGq, N = 8; UCMS/hM3DGq, N = 9). Data are presented as the mean ± SEM.
    Adeno Associated Virus (Aav) Designer Receptors Exclusively Activated By Designer Drug (Dreadd) Vectors, supplied by Addgene inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Activation of prefrontal PV + neurons in male mice affects the expression of anxiety-like and depressive-like behaviors under baseline and stressful conditions. Top left, Representative image of <t>mCherry-DREADD</t> virus expression in the PrL and IL regions of <t>the</t> <t>PFC.</t> Top right, Schematic representation of experimental design. a–d , In the EPM test, UCMS interacted with the chronic activation of prefrontal PV + neurons to modulate the time spent in the open arms ( a ; * p = 0.0441; ** p = 0.0052), but no other significant interactions were observed. e – h , In the OF test, UCMS decreased time in the center ( e ; * p = 0.011), increased thigmotaxis ratio ( g ; * p = 0.0244), and increased overall activity ( h ; ** p = 0.0019). i , j , In the marble-burying test, a significant UCMS effect was driven by a higher number of marbles buried by UCMS/hM3DGq mice compared with their nonstressed controls (** p = 0.0038; i ); a similar effect was observed in the splash test ( j ), with decreased time spent grooming by UCMS/hM3DGq mice compared with their nonstressed controls (** p = 0.0088). k , In the CPA test, significant effects of stress and virus were detected; Tukey’s post hoc analyses revealed that the aversion score of mice from the UCMS/hM3DGq was lower than that of control mice (* p = 0.021). N = 8–11/group (C/mCherry, N = 8; UCMS/mCherry, N = 11; C/hM3DGq, N = 8; UCMS/hM3DGq, N = 9). Data are presented as the mean ± SEM.
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    Activation of prefrontal PV + neurons in male mice affects the expression of anxiety-like and depressive-like behaviors under baseline and stressful conditions. Top left, Representative image of <t>mCherry-DREADD</t> virus expression in the PrL and IL regions of <t>the</t> <t>PFC.</t> Top right, Schematic representation of experimental design. a–d , In the EPM test, UCMS interacted with the chronic activation of prefrontal PV + neurons to modulate the time spent in the open arms ( a ; * p = 0.0441; ** p = 0.0052), but no other significant interactions were observed. e – h , In the OF test, UCMS decreased time in the center ( e ; * p = 0.011), increased thigmotaxis ratio ( g ; * p = 0.0244), and increased overall activity ( h ; ** p = 0.0019). i , j , In the marble-burying test, a significant UCMS effect was driven by a higher number of marbles buried by UCMS/hM3DGq mice compared with their nonstressed controls (** p = 0.0038; i ); a similar effect was observed in the splash test ( j ), with decreased time spent grooming by UCMS/hM3DGq mice compared with their nonstressed controls (** p = 0.0088). k , In the CPA test, significant effects of stress and virus were detected; Tukey’s post hoc analyses revealed that the aversion score of mice from the UCMS/hM3DGq was lower than that of control mice (* p = 0.021). N = 8–11/group (C/mCherry, N = 8; UCMS/mCherry, N = 11; C/hM3DGq, N = 8; UCMS/hM3DGq, N = 9). Data are presented as the mean ± SEM.
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    Image Search Results


    Activation of prefrontal PV + neurons in male mice affects the expression of anxiety-like and depressive-like behaviors under baseline and stressful conditions. Top left, Representative image of mCherry-DREADD virus expression in the PrL and IL regions of the PFC. Top right, Schematic representation of experimental design. a–d , In the EPM test, UCMS interacted with the chronic activation of prefrontal PV + neurons to modulate the time spent in the open arms ( a ; * p = 0.0441; ** p = 0.0052), but no other significant interactions were observed. e – h , In the OF test, UCMS decreased time in the center ( e ; * p = 0.011), increased thigmotaxis ratio ( g ; * p = 0.0244), and increased overall activity ( h ; ** p = 0.0019). i , j , In the marble-burying test, a significant UCMS effect was driven by a higher number of marbles buried by UCMS/hM3DGq mice compared with their nonstressed controls (** p = 0.0038; i ); a similar effect was observed in the splash test ( j ), with decreased time spent grooming by UCMS/hM3DGq mice compared with their nonstressed controls (** p = 0.0088). k , In the CPA test, significant effects of stress and virus were detected; Tukey’s post hoc analyses revealed that the aversion score of mice from the UCMS/hM3DGq was lower than that of control mice (* p = 0.021). N = 8–11/group (C/mCherry, N = 8; UCMS/mCherry, N = 11; C/hM3DGq, N = 8; UCMS/hM3DGq, N = 9). Data are presented as the mean ± SEM.

    Journal: eNeuro

    Article Title: Sex-Specific Timelines for Adaptations of Prefrontal Parvalbumin Neurons in Response to Stress and Changes in Anxiety- and Depressive-Like Behaviors

    doi: 10.1523/ENEURO.0300-22.2023

    Figure Lengend Snippet: Activation of prefrontal PV + neurons in male mice affects the expression of anxiety-like and depressive-like behaviors under baseline and stressful conditions. Top left, Representative image of mCherry-DREADD virus expression in the PrL and IL regions of the PFC. Top right, Schematic representation of experimental design. a–d , In the EPM test, UCMS interacted with the chronic activation of prefrontal PV + neurons to modulate the time spent in the open arms ( a ; * p = 0.0441; ** p = 0.0052), but no other significant interactions were observed. e – h , In the OF test, UCMS decreased time in the center ( e ; * p = 0.011), increased thigmotaxis ratio ( g ; * p = 0.0244), and increased overall activity ( h ; ** p = 0.0019). i , j , In the marble-burying test, a significant UCMS effect was driven by a higher number of marbles buried by UCMS/hM3DGq mice compared with their nonstressed controls (** p = 0.0038; i ); a similar effect was observed in the splash test ( j ), with decreased time spent grooming by UCMS/hM3DGq mice compared with their nonstressed controls (** p = 0.0088). k , In the CPA test, significant effects of stress and virus were detected; Tukey’s post hoc analyses revealed that the aversion score of mice from the UCMS/hM3DGq was lower than that of control mice (* p = 0.021). N = 8–11/group (C/mCherry, N = 8; UCMS/mCherry, N = 11; C/hM3DGq, N = 8; UCMS/hM3DGq, N = 9). Data are presented as the mean ± SEM.

    Article Snippet: Adeno-associated virus (AAV) designer receptors exclusively activated by designer drug (DREADD) vectors (Addgene) were stereotaxically infused in the ventromedial PFC (including the central part of the PrL and IL cortices) of male PV:Cre mice.

    Techniques: Activation Assay, Expressing, Virus, Activity Assay, Control